Dosing That Fits Into Your Day, Every Day

Take SEPHIENCE once a day with food.

Take SEPHIENCE once a day with food.

It’s recommended to take it at the same time each day. Additional food intake is required after dosing.

During treatment with SEPHIENCE, you or your child will have regular check-ups 
with your healthcare provider.

  • Your healthcare provider will do blood tests before and during treatment to check blood Phe levels.
  • They may change your dose, temporarily stop, or permanently stop treatment if certain side effects occur.
  • They may also change your diet. Follow their instructions and don’t make dietary changes without talking to them.

Follow these steps to take SEPHIENCE

1

Prepare

Mix the correct number of packets with water, 
apple juice, or soft food (only for doses ≥1000 mg),  such as applesauce or strawberry jam
2

Mix until combined

  • Stir liquids for at least 30 seconds
  • Stir soft foods for at least 60 seconds
  • Oral powder is not expected to dissolve completely. This is normal
3

Use as directed

  • Drink or swallow the full amount
  • For doses <1000 mg: Use an oral syringe to draw up the prescribed dose and administer
4

Rinse & finish

  • Rinse the cup or syringe with water or juice
  • Swallow the rinse until clean to make sure you get the full dose
5

If you need to store it

  • If not taken right away, cover and store the mix:
    • In the refrigerator (36°F to 46°F / 2°C to 8°C) for up to 24 hours
    • At room temperature (68°F to 77°F / 20°C to 25°C) for up to 6 hours
  • Stir again before using (see step 2) for at least 30 to 60 seconds

How to Mix SEPHIENCE

Comes in 250 mg 
and 1000 mg 
powder packets



Mix with water or apple juice

For doses 1000 mg or higher, you can also mix with soft foods, like applesauce or strawberry jam

Caution

May cause staining when in contact with certain surfaces. To minimize the risk, use as directed.

SEPHIENCE Dosing Calculator

Are you unsure which dose is right for you or your loved one? Your doctor will determine the correct dose based on the age and weight of the person taking SEPHIENCE. Enter the information below for a simple way to see the dose.

Patient Age:

Months

Patient Weight:

kg

Total Dose Per Day (mg)

mg

Administered Dose Volume Per Day:

ml

Total Daily SEPHIENCE:

mg

packet x

This dosing calculator is designed to help you or someone you care for understand how a dose is calculated.
It’s for informational purposes only and doesn’t replace medical advice. Your doctor will determine the correct dose based on individual needs.

Need extra support with SEPHIENCE?

Our dedicated PTC Cares™ support team are here to help. Connect with one today 
for personalized guidance and answers to your questions.

Always take SEPHIENCE as your doctor prescribes. For more information, contact your PTC Cares™ Case Managers. 

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